Proteolytic processing induces a conformational switch required for antibacterial toxin delivery

Many Gram-negative bacteria use CdiA effector proteins to inhibit the growth of neighboring competitors. CdiA transfers its toxic CdiA-CT region into the periplasm of target cells, where it is released through proteolytic cleavage. The N-terminal cytoplasm-entry domain of the CdiA-CT then mediates t...

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Detalles Bibliográficos
Autores principales: Bartelli, Nicholas L., Passanisi, Victor J., Michalska, Karolina, Song, Kiho, Nhan, Dinh Q., Zhou, Hongjun, Cuthbert, Bonnie J., Stols, Lucy M., Eschenfeldt, William H., Wilson, Nicholas G., Basra, Jesse S., Cortes, Ricardo, Noorsher, Zainab, Gabraiel, Youssef, Poonen-Honig, Isaac, Seacord, Elizabeth C., Goulding, Celia W., Low, David A., Joachimiak, Andrzej, Dahlquist, Frederick W., Hayes, Christopher S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9424206/
https://www.ncbi.nlm.nih.gov/pubmed/36038560
http://dx.doi.org/10.1038/s41467-022-32795-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9424206/
https://www.ncbi.nlm.nih.gov/pubmed/36038560
http://dx.doi.org/10.1038/s41467-022-32795-y

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