CKD-581 Downregulates Wnt/β-Catenin Pathway by DACT3 Induction in Hematologic Malignancy

The present study evaluated the anti-cancer activity of histone deacetylase (HDAC)-inhibiting CKD-581 in multiple myeloma (MM) and its pharmacological mechanisms. CKD-581 potently inhibited a broad spectrum of HDAC isozymes. It concentration-dependently inhibited proliferation of hematologic cancer...

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Detalles Bibliográficos
Autores principales: Kim, Soo Jin, Kim, Suntae, Choi, Yong June, Kim, U Ji, Kang, Keon Wook
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Applied Pharmacology 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9424334/
https://www.ncbi.nlm.nih.gov/pubmed/35794797
http://dx.doi.org/10.4062/biomolther.2022.022

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9424334/
https://www.ncbi.nlm.nih.gov/pubmed/35794797
http://dx.doi.org/10.4062/biomolther.2022.022

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