Cargando…

CKD-581 Downregulates Wnt/β-Catenin Pathway by DACT3 Induction in Hematologic Malignancy

The present study evaluated the anti-cancer activity of histone deacetylase (HDAC)-inhibiting CKD-581 in multiple myeloma (MM) and its pharmacological mechanisms. CKD-581 potently inhibited a broad spectrum of HDAC isozymes. It concentration-dependently inhibited proliferation of hematologic cancer...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kim, Soo Jin, Kim, Suntae, Choi, Yong June, Kim, U Ji, Kang, Keon Wook
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Korean Society of Applied Pharmacology 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9424334/ https://www.ncbi.nlm.nih.gov/pubmed/35794797 http://dx.doi.org/10.4062/biomolther.2022.022

Ejemplares similares

Anti-Cancer Effects of CKD-581, a Potent Histone Deacetylase Inhibitor against Diffuse Large B-Cell Lymphoma
por: Kim, Soo Jin, et al.
Publicado: (2020)

Targeting the canonical Wnt/β-catenin pathway in hematological malignancies
por: Ashihara, Eishi, et al.
Publicado: (2015)

Dact1, a Nutritionally Regulated Preadipocyte Gene, Controls Adipogenesis by Coordinating the Wnt/β-Catenin Signaling Network
por: Lagathu, Claire, et al.
Publicado: (2009)

DACT1, an antagonist to Wnt/β-catenin signaling, suppresses tumor cell growth and is frequently silenced in breast cancer
por: Yin, Xuedong, et al.
Publicado: (2013)

Dact2 Represses PITX2 Transcriptional Activation and Cell Proliferation through Wnt/beta-Catenin Signaling during Odontogenesis
por: Li, Xiao, et al.
Publicado: (2013)

Oncogenic Function of DACT1 in Colon Cancer through the Regulation of β-catenin
por: Yuan, Guohong, et al.
Publicado: (2012)

DACT2 is a functional tumor suppressor through inhibiting Wnt/β-catenin pathway and associated with poor survival in colon cancer
por: Wang, S, et al.
Publicado: (2015)

Methylation of DACT2 accelerates esophageal cancer development by activating Wnt signaling
por: Zhang, Meiying, et al.
Publicado: (2016)

Methylation of DACT2 promotes breast cancer development by activating Wnt signaling
por: Li, Jingyi, et al.
Publicado: (2017)

Downregulation of DACT-2 by Promoter Methylation and its Clinicopathological Significance in Prostate Cancer
por: Li, Shibao, et al.
Publicado: (2019)

Dact genes are chordate specific regulators at the intersection of Wnt and Tgf-β signaling pathways
por: Schubert, Frank Richard, et al.
Publicado: (2014)

Methylation of DACT2 Promotes Papillary Thyroid Cancer Metastasis by Activating Wnt Signaling
por: Zhao, Zhiyan, et al.
Publicado: (2014)

MiR-324-3p promotes tumor growth through targeting DACT1 and activation of Wnt/β-catenin pathway in hepatocellular carcinoma
por: Tuo, Hang, et al.
Publicado: (2017)

Dapper Antagonist of Catenin-1 (Dact1) contributes to dendrite arborization in forebrain cortical interneurons
por: Arguello, Annie, et al.
Publicado: (2013)

WNT Signaling in Hematological Malignancies
por: Frenquelli, Michela, et al.
Publicado: (2020)

581 Chronic Urticaria and Infections
por: Aguilar, Nadia, et al.
Publicado: (2012)

DACT1 Overexpression in type I ovarian cancer inhibits malignant expansion and cis-platinum resistance by modulating canonical Wnt signalling and autophagy
por: Li, Ruo-nan, et al.
Publicado: (2017)

TGF-β-induced DACT1 Biomolecular Condensates Repress Wnt Signaling To Promote Bone Metastasis
por: Esposito, Mark, et al.
Publicado: (2021)

Aberrant methylation of DACT1 and DACT2 are associated with tumor progression and poor prognosis in esophageal squamous cell carcinoma
por: Guo, Yan-li, et al.
Publicado: (2017)

SUN-581 An Unusual Presentation of Hypothyroidism
por: Alim, Hussam, et al.
Publicado: (2019)

TET1 exerts its anti-tumor functions via demethylating DACT2 and SFRP2 to antagonize Wnt/β-catenin signaling pathway in nasopharyngeal carcinoma cells
por: Fan, Jiangxia, et al.
Publicado: (2018)

Downregulated Wnt/β-catenin signalling in the Down syndrome hippocampus
por: Granno, Simone, et al.
Publicado: (2019)

Role of Wnt canonical pathway in hematological malignancies
por: GE, Xueling, et al.
Publicado: (2010)

Extracorporeal Life Support in Patients with Hematologic Malignancies: A Single Center Experience
por: Choi, Kuk Bin, et al.
Publicado: (2016)

Abstract 31: Irf6 Regulates The Wnt Signaling Pathway During Craniofacial Development Through The Regulation Of Dact Expression
por: Carroll, Shannon H., et al.
Publicado: (2020)

dact1/2 modifies noncanonical Wnt signaling and calpain 8 expression to regulate convergent extension and craniofacial development
por: Carroll, Shannon H., et al.
Publicado: (2023)

The Role of DACT Family Members in Tumorigenesis and Tumor Progression
por: Zeng, Yu, et al.
Publicado: (2022)

Ginsenoside Rb1 ameliorates CKD‐associated vascular calcification by inhibiting the Wnt/β‐catenin pathway
por: Zhou, Peng, et al.
Publicado: (2019)

Correction to Lancet Oncol 2021; 22: 581–83
Publicado: (2021)

581 Sustained Multidisciplinary CLABSI Bundle in the Burn Center
por: Dao, Sylvia H, et al.
Publicado: (2022)

581. The Epidemiology of Imipenem-Resistant Acinetobacter baumannii Bacteremia in a Pediatric Intensive Care Unit and Carbapenem Use
por: Kim, Dongsub, et al.
Publicado: (2019)

Multicenter retrospective analysis of 581 patients with primary intestinal non-hodgkin lymphoma from the Consortium for Improving Survival of Lymphoma (CISL)
por: Kim, Seok Jin, et al.
Publicado: (2011)

Olig2-Induced Neural Stem Cell Differentiation Involves Downregulation of Wnt Signaling and Induction of Dickkopf-1 Expression
por: Ahn, Sung-Min, et al.
Publicado: (2008)

Clarinet quintet, K. 581 Clarinet quartet, K. 374f ; Quintet for clarinet, basset-horn and string trio /
por: Mozart, Wolfgang Amadeus, 1756-1791
Publicado: (1993)

Anti-metastatic effect of GV1001 on prostate cancer cells; roles of GnRHR-mediated Gαs-cAMP pathway and AR-YAP1 axis
por: Kim, Ji Won, et al.
Publicado: (2021)

Inhibition of the Wnt palmitoyltransferase porcupine suppresses cell growth and downregulates the Wnt/β-catenin pathway in gastric cancer
por: MO, MIN-LI, et al.
Publicado: (2013)

The role of aberrant promoter hypermethylation of DACT1 in bladder urothelial carcinoma
por: Cheng, Huan, et al.
Publicado: (2012)

DACT2 regulates structural and electrical atrial remodeling in atrial fibrillation
por: Hou, Jian, et al.
Publicado: (2020)

Effects of DACT1 methylation status on invasion and metastasis of nasopharyngeal carcinoma
por: Yang, Ju-Hong, et al.
Publicado: (2019)

First complete mitochondrial genome of Phoenix dact ylifera var. Khanezi
por: Asaf, Sajjad, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_449s7tvi7glfned4skht57dva9