Small molecule mediated inhibition of protein cargo recognition by peroxisomal transport receptor PEX5 is toxic to Trypanosoma

Trypanosomiases are life-threatening infections of humans and livestock, and novel effective therapeutic approaches are needed. Trypanosoma compartmentalize glycolysis into specialized organelles termed glycosomes. Most of the trypanosomal glycolytic enzymes harbor a peroxisomal targeting signal-1 (...

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Detalles Bibliográficos
Autores principales: Napolitano, Valeria, Softley, Charlotte A., Blat, Artur, Kalel, Vishal C., Schorpp, Kenji, Siebenmorgen, Till, Hadian, Kamyar, Erdmann, Ralf, Sattler, Michael, Popowicz, Grzegorz M., Dubin, Grzegorz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9424529/
https://www.ncbi.nlm.nih.gov/pubmed/36038611
http://dx.doi.org/10.1038/s41598-022-18841-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9424529/
https://www.ncbi.nlm.nih.gov/pubmed/36038611
http://dx.doi.org/10.1038/s41598-022-18841-1

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