HDAC inhibitors Panobinostat and Romidepsin enhance tax transcription in HTLV-1-infected cell lines and freshly isolated patients’ T-cells

The viral transactivator Tax plays a key role in HTLV-1 reactivation and de novo infection. Previous approaches focused on the histone deacetylase inhibitor (HDACi) Valproate as a latency-reversing agent to boost Tax expression and expose infected cells to the host’s immune response. However, follow...

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Detalles Bibliográficos
Autores principales: Schnell, Annika P., Kohrt, Stephan, Aristodemou, Aris, Taylor, Graham P., Bangham, Charles R. M., Thoma-Kress, Andrea K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9424546/
https://www.ncbi.nlm.nih.gov/pubmed/36052071
http://dx.doi.org/10.3389/fimmu.2022.978800

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9424546/
https://www.ncbi.nlm.nih.gov/pubmed/36052071
http://dx.doi.org/10.3389/fimmu.2022.978800

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