Cargando…

HDAC inhibitors Panobinostat and Romidepsin enhance tax transcription in HTLV-1-infected cell lines and freshly isolated patients’ T-cells

The viral transactivator Tax plays a key role in HTLV-1 reactivation and de novo infection. Previous approaches focused on the histone deacetylase inhibitor (HDACi) Valproate as a latency-reversing agent to boost Tax expression and expose infected cells to the host’s immune response. However, follow...

Descripción completa

Detalles Bibliográficos
Autores principales:	Schnell, Annika P., Kohrt, Stephan, Aristodemou, Aris, Taylor, Graham P., Bangham, Charles R. M., Thoma-Kress, Andrea K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9424546/ https://www.ncbi.nlm.nih.gov/pubmed/36052071 http://dx.doi.org/10.3389/fimmu.2022.978800

Ejemplares similares

Latency Reversing Agents: Kick and Kill of HTLV-1?
por: Schnell, Annika P., et al.
Publicado: (2021)

The transcriptome of HTLV-1-infected primary cells following reactivation reveals changes to host gene expression central to the proviral life cycle
por: Aristodemou, Aris E. N., et al.
Publicado: (2023)

Susceptibility of HBZ and Tax expressing primary HTLV-1+ T cell clones to CTL lysis
por: Rowan, Aileen G, et al.
Publicado: (2011)

Characterizing the Interaction between the HTLV-1 Transactivator Tax-1 with Transcription Elongation Factor ELL2 and Its Impact on Viral Transactivation
por: Kohrt, Stephan, et al.
Publicado: (2021)

A novel positive feedback-loop between the HTLV-1 oncoprotein Tax and NF-κB activity in T-cells
por: Millen, Sebastian, et al.
Publicado: (2020)

Cytotoxic T lymphocyte lysis of HTLV-1 infected cells is limited by weak HBZ protein expression, but non-specifically enhanced on induction of Tax expression
por: Rowan, Aileen G, et al.
Publicado: (2014)

The Tax-Inducible Actin-Bundling Protein Fascin Is Crucial for Release and Cell-to-Cell Transmission of Human T-Cell Leukemia Virus Type 1 (HTLV-1)
por: Gross, Christine, et al.
Publicado: (2016)

Synergistic Tumor Cytolysis by NK Cells in Combination With a Pan-HDAC Inhibitor, Panobinostat
por: Afolabi, Lukman O., et al.
Publicado: (2021)

HTLV-1 gene expression by individual infected clones determines susceptibility to lysis by cytotoxic T lymphocytes specific for Tax and HBZ
por: Rowan, Aileen G, et al.
Publicado: (2014)

The HTLV-1 Tax interactome
por: Boxus, Mathieu, et al.
Publicado: (2008)

Design and synthesis of diazine-based panobinostat analogues for HDAC8 inhibition
por: Balasubramaniam, Sivaraman, et al.
Publicado: (2020)

IDH1 mutant glioma is preferentially sensitive to the HDAC inhibitor panobinostat
por: Sears, Thomas K., et al.
Publicado: (2021)

Molecular Mechanisms of HTLV-1 Cell-to-Cell Transmission
por: Gross, Christine, et al.
Publicado: (2016)

HDAC1/2 Inhibitor Romidepsin Suppresses DEN-Induced Hepatocellular Carcinogenesis in Mice
por: Afaloniati, Hara, et al.
Publicado: (2020)

HDAC Screening Identifies the HDAC Class I Inhibitor Romidepsin as a Promising Epigenetic Drug for Biliary Tract Cancer
por: Mayr, Christian, et al.
Publicado: (2021)

Romidepsin in the treatment of cutaneous T-cell lymphoma
por: Jain, Salvia, et al.
Publicado: (2011)

Romidepsin for the Treatment of Peripheral T-Cell Lymphoma
por: Barbarotta, Lisa, et al.
Publicado: (2015)

Mechanisms of Oncogenesis by HTLV-1 Tax
por: Mohanty, Suchitra, et al.
Publicado: (2020)

SUV39H1 interacts with HTLV-1 Tax and abrogates Tax transactivation of HTLV-1 LTR
por: Kamoi, Koju, et al.
Publicado: (2006)

Transformation of human embryonic stem cells by HTLV-1 Tax
por: Zane, Linda, et al.
Publicado: (2011)

Distinct activities of HTLV-1 Tax1 from HTLV-2 Tax2 play key roles in pathogenesis
por: Fujii, Masahiro, et al.
Publicado: (2011)

Clonality of HTLV-1 differs between infected CD8+ T cells and infected CD4+ T cells in vivo
por: Melamed, Anat, et al.
Publicado: (2014)

High frequency of CD4(+)FoxP3(+) cells in HTLV-1 infection: inverse correlation with HTLV-1–specific CTL response
por: Toulza, Frederic, et al.
Publicado: (2008)

HTLV-1 Tax: centrosome amplification and cancer
por: Pumfery, Anne, et al.
Publicado: (2006)

The importance of ubiquitination and sumoylation on the transforming activity of HTLV Tax-1 and Tax-2
por: Zane, Linda, et al.
Publicado: (2012)

HTLV-1 clonality in adult T-cell leukaemia and non-malignant HTLV-1 infection
por: Bangham, Charles R.M., et al.
Publicado: (2014)

Efficacy of HDAC Inhibitors Belinostat and Panobinostat against Cisplatin-Sensitive and Cisplatin-Resistant Testicular Germ Cell Tumors
por: Lobo, João, et al.
Publicado: (2020)

Distinct functions of HTLV-1 Tax1 from HTLV-2 Tax2 contribute key roles to viral pathogenesis
por: Higuchi, Masaya, et al.
Publicado: (2009)

Expression of the HBZ and tax genes of HTLV-1in infective dermatitis associated with HTLV-I (IDH)
por: Batista, Everton S, et al.
Publicado: (2011)

Deciphering the molecular effects of romidepsin on germ cell tumours: DHRS2 is involved in cell cycle arrest but not apoptosis or induction of romidepsin effectors
por: Nettersheim, Daniel, et al.
Publicado: (2018)

HTLV-1 persistence and the oncogenesis of adult T-cell leukemia/lymphoma
por: Bangham, Charles R. M.
Publicado: (2023)

R-Loop–Mediated ssDNA Breaks Accumulate Following Short-Term Exposure to the HDAC Inhibitor Romidepsin
por: Safari, Maryam, et al.
Publicado: (2021)

Expression of histone deacetylase (HDAC) family members in bortezomib-refractory multiple myeloma and modulation by panobinostat
por: Cheng, Tiewei, et al.
Publicado: (2021)

In vitro and in vivo anti−Toxoplasma activities of HDAC inhibitor Panobinostat on experimental acute ocular toxoplasmosis
por: Zhang, Yu, et al.
Publicado: (2022)

Romidepsin-induced neutrophilic urticaria
por: Scott, Brian, et al.
Publicado: (2016)

Human T-lymphotropic virus type 1(HTLV-1) integration, HTLV-1-associated infective dermatitis (IDH) and the risk of Adult T cell leukaemia/lymphoma (ATLL)
por: Hlela, Carol, et al.
Publicado: (2011)

Tolerability to romidepsin in patients with relapsed/refractory T-cell lymphoma
por: Foss, Francine, et al.
Publicado: (2014)

Transcriptome analysis of HTLV-1-infected cells in comparison to the normal and Tax-expressing T cells
por: Singh, Shruti, et al.
Publicado: (2011)

Move or Die: the Fate of the Tax Oncoprotein of HTLV-1
por: Lodewick, Julie, et al.
Publicado: (2011)

Expression and purification of the HTLV-1 transforming protein Tax
por: Evans, Whitney, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_5k5m00h6nati1hn0no764incot