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Elevated de novo lipogenesis, slow liver triglyceride turnover, and clinical correlations in nonalcoholic steatohepatitis patients

De novo lipogenesis (DNL) converts carbon substrates to lipids. Increased hepatic DNL could contribute to pathogenic liver triglyceride accumulation in nonalcoholic steatohepatitis (NASH) and therefore may be a potential target for pharmacological intervention. Here, we measured hepatic DNL using he...

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Detalles Bibliográficos
Autores principales: Lawitz, Eric J., Li, Kelvin W., Nyangau, Edna, Field, Tyler John, Chuang, Jen-Chieh, Billin, Andrew, Wang, Lulu, Wang, Ya, Huss, Ryan S., Chung, Chuhan, Subramanian, G. Mani, Myers, Robert P., Hellerstein, Marc K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9424583/
https://www.ncbi.nlm.nih.gov/pubmed/35835205
http://dx.doi.org/10.1016/j.jlr.2022.100250