MUC1-mediated Macrophage Activation Promotes Colitis-associated Colorectal Cancer via Activating the Interleukin-6/ Signal Transducer and Activator of Transcription 3 Axis

BACKGROUND & AIMS: MUC1 is abnormally expressed in colorectal cancer, including colitis-associated colorectal cancer (CAC), but its role in tumorigenesis is unclear. This study investigated MUC1’s effects in murine models of colitis and CAC and elucidated mechanisms of action. METHODS: Colitis a...

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Detalles Bibliográficos
Autores principales: Sheng, Yong H., Davies, Julie M., Wang, Ran, Wong, Kuan Yau, Giri, Rabina, Yang, Yuanhao, Begun, Jakob, Florin, Timothy H., Hasnain, Sumaira Z., McGuckin, Michael A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9424590/
https://www.ncbi.nlm.nih.gov/pubmed/35809803
http://dx.doi.org/10.1016/j.jcmgh.2022.06.010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9424590/
https://www.ncbi.nlm.nih.gov/pubmed/35809803
http://dx.doi.org/10.1016/j.jcmgh.2022.06.010

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