Population pharmacokinetic/pharmacodynamic analysis of AK111, an IL-17A monoclonal antibody, in subjects with moderate-to-severe plaque psoriasis

AK111 is an innovative IL-17A antibody, presenting high affinity to IL-17A and showing similar pharmacokinetic (PK) characteristics to those of typical immunoglobulin (Ig) G1 antibodies. To optimize the dosage regimen for phase 2/3 clinical trials, PK and pharmacodynamics (PD) of AK111 were first ch...

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Detalles Bibliográficos
Autores principales: Li, Qian, Qiao, Ju, Jin, Hongzhong, Chen, Benchao, He, Zhimei, Wang, Guoqin, Ni, Xiang, Wang, Max, Xia, Michelle, Li, Baiyong, Chen, Rui, Hu, Pei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9424636/
https://www.ncbi.nlm.nih.gov/pubmed/36052126
http://dx.doi.org/10.3389/fphar.2022.966176

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9424636/
https://www.ncbi.nlm.nih.gov/pubmed/36052126
http://dx.doi.org/10.3389/fphar.2022.966176

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