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Circulating histones contribute to monocyte and MDW alterations as common mediators in classical and COVID-19 sepsis

OBJECTIVE: Histone proteins are physiologically involved in DNA packaging and gene regulation but are extracellularly released by neutrophil/monocyte extracellular traps and mediate thrombo-inflammatory pathways, associated to the severity of many human pathologies, including bacterial/fungal sepsis...

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Detalles Bibliográficos
Autores principales: Ligi, Daniela, Lo Sasso, Bruna, Giglio, Rosaria Vincenza, Maniscalco, Rosanna, DellaFranca, Chiara, Agnello, Luisa, Ciaccio, Marcello, Mannello, Ferdinando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9424804/
https://www.ncbi.nlm.nih.gov/pubmed/36042461
http://dx.doi.org/10.1186/s13054-022-04138-2