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Circulating histones contribute to monocyte and MDW alterations as common mediators in classical and COVID-19 sepsis
OBJECTIVE: Histone proteins are physiologically involved in DNA packaging and gene regulation but are extracellularly released by neutrophil/monocyte extracellular traps and mediate thrombo-inflammatory pathways, associated to the severity of many human pathologies, including bacterial/fungal sepsis...
Autores principales: | Ligi, Daniela, Lo Sasso, Bruna, Giglio, Rosaria Vincenza, Maniscalco, Rosanna, DellaFranca, Chiara, Agnello, Luisa, Ciaccio, Marcello, Mannello, Ferdinando |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9424804/ https://www.ncbi.nlm.nih.gov/pubmed/36042461 http://dx.doi.org/10.1186/s13054-022-04138-2 |
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