Preclinical Pharmacokinetics and In Vitro Properties of GS-441524, a Potential Oral Drug Candidate for COVID-19 Treatment

Preclinical pharmacokinetics (PK) and In Vitro ADME properties of GS-441524, a potential oral agent for the treatment of Covid-19, were studied. GS-441524 was stable in vitro in liver microsomes, cytosols, and hepatocytes of mice, rats, monkeys, dogs, and humans. The plasma free fractions of GS-4415...

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Detalles Bibliográficos
Autores principales: Wang, Amy Q., Hagen, Natalie R., Padilha, Elias C., Yang, Mengbi, Shah, Pranav, Chen, Catherine Z., Huang, Wenwei, Terse, Pramod, Sanderson, Philip, Zheng, Wei, Xu, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9424906/
https://www.ncbi.nlm.nih.gov/pubmed/36052127
http://dx.doi.org/10.3389/fphar.2022.918083

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9424906/
https://www.ncbi.nlm.nih.gov/pubmed/36052127
http://dx.doi.org/10.3389/fphar.2022.918083

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