Glial activation in prion diseases is selectively triggered by neuronal PrP(Sc)

Although prion infections cause cognitive impairment and neuronal death, transcriptional and translational profiling shows progressive derangement within glia but surprisingly little changes within neurons. Here we expressed PrP(C) selectively in neurons and astrocytes of mice. After prion infection...

Descripción completa

Detalles Bibliográficos
Autores principales: Lakkaraju, Asvin K. K., Sorce, Silvia, Senatore, Assunta, Nuvolone, Mario, Guo, Jingjing, Schwarz, Petra, Moos, Rita, Pelczar, Pawel, Aguzzi, Adriano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9425016/
https://www.ncbi.nlm.nih.gov/pubmed/35178783
http://dx.doi.org/10.1111/bpa.13056

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9425016/
https://www.ncbi.nlm.nih.gov/pubmed/35178783
http://dx.doi.org/10.1111/bpa.13056

Ejemplares similares