Mechanistic insights on novel small molecule allosteric activators of cGMP-dependent protein kinase PKG1α

cGMP-dependent protein kinase (PKG) represents a compelling drug target for treatment of cardiovascular diseases. PKG1 is the major effector of beneficial cGMP signaling which is involved in smooth muscle relaxation and vascular tone, inhibition of platelet aggregation and signaling that leads to ca...

Descripción completa

Detalles Bibliográficos
Autores principales: Tawa, Paul, Zhang, Lei, Metwally, Essam, Hou, Yan, McCoy, Mark A., Seganish, W. Michael, Zhang, Rumin, Frank, Emily, Sheth, Payal, Hanisak, Jennifer, Sondey, Christopher, Bauman, David, Soriano, Aileen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9425037/
https://www.ncbi.nlm.nih.gov/pubmed/35868561
http://dx.doi.org/10.1016/j.jbc.2022.102284

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9425037/
https://www.ncbi.nlm.nih.gov/pubmed/35868561
http://dx.doi.org/10.1016/j.jbc.2022.102284

Ejemplares similares