Mechanistic insights on novel small molecule allosteric activators of cGMP-dependent protein kinase PKG1α
cGMP-dependent protein kinase (PKG) represents a compelling drug target for treatment of cardiovascular diseases. PKG1 is the major effector of beneficial cGMP signaling which is involved in smooth muscle relaxation and vascular tone, inhibition of platelet aggregation and signaling that leads to ca...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Biochemistry and Molecular Biology
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9425037/ https://www.ncbi.nlm.nih.gov/pubmed/35868561 http://dx.doi.org/10.1016/j.jbc.2022.102284 |