Cargando…

Elafin Reverses Intestinal Fibrosis by Inhibiting Cathepsin S-Mediated Protease-Activated Receptor 2

BACKGROUND & AIMS: More than half of Crohn’s disease patients develop intestinal fibrosis-induced intestinal strictures. Elafin is a human protease inhibitor that is down-regulated in the stricturing intestine of Crohn’s disease patients. We investigated the efficacy of elafin in reversing intes...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xie, Ying, Fontenot, Lindsey, Chupina Estrada, Andrea, Nelson, Becca, Wang, Jiani, Shih, David Q., Ho, Wendy, Mattai, S. Anjani, Rieder, Florian, Jensen, Dane D., Bunnett, Nigel W., Koon, Hon Wai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9425040/ https://www.ncbi.nlm.nih.gov/pubmed/35840034 http://dx.doi.org/10.1016/j.jcmgh.2022.06.011

Ejemplares similares

High circulating elafin levels are associated with Crohn’s disease-associated intestinal strictures
por: Wang, Jiani, et al.
Publicado: (2020)

Elafin inhibits obesity, hyperglycemia, and liver steatosis in high-fat diet-treated male mice
por: Wang, Jiani, et al.
Publicado: (2020)

ADS024, a Bacillus velezensis strain, protects human colonic epithelial cells against C. difficile toxin-mediated apoptosis
por: Xie, Ying, et al.
Publicado: (2023)

Proteolytic activation of the epithelial sodium channel (ENaC) by the cysteine protease cathepsin-S
por: Haerteis, Silke, et al.
Publicado: (2012)

Circulating cathelicidin levels correlate with mucosal disease activity in ulcerative colitis, risk of intestinal stricture in Crohn’s disease, and clinical prognosis in inflammatory bowel disease
por: Tran, Diana Hoang-Ngoc, et al.
Publicado: (2017)

Differential effects of periopathogens on host protease inhibitors SLPI, elafin, SCCA1, and SCCA2
por: Yin, Lei, et al.
Publicado: (2010)

The Serine Protease Inhibitor Elafin Maintains Normal Growth Control by Opposing the Mitogenic Effects of Neutrophil Elastase
por: Caruso, Joseph A., et al.
Publicado: (2014)

Biased Signaling of Protease-Activated Receptors
por: Zhao, Peishen, et al.
Publicado: (2014)

Corrigendum: Biased Signaling of Protease-Activated Receptors
por: Zhao, Peishen, et al.
Publicado: (2015)

Secretory Leukocyte Protease Inhibitor (SLPI) Is, like Its Homologue Trappin-2 (Pre-Elafin), a Transglutaminase Substrate
por: Baranger, Kévin, et al.
Publicado: (2011)

Host Cell Proteases: Cathepsins
por: Brix, Klaudia
Publicado: (2018)

Elafin: a double agent in breast and ovarian cancer
por: Feng, Yi, et al.
Publicado: (2015)

High Expression and Clinical Significance of Elafin in Colorectal Cancer
por: Liu, Yun, et al.
Publicado: (2019)

Metabolic Syndrome, Clusterin and Elafin in Patients with Psoriasis Vulgaris
por: Holmannova, Drahomira, et al.
Publicado: (2020)

Reframing Palliative Care: An East-West Integrative Palliative Care Model
por: Mattai, S. Anjani D., et al.
Publicado: (2021)

Immunohistochemical expression of SKALP/elafin in squamous cell carcinoma of the oesophagus.
por: Yamamoto, S., et al.
Publicado: (1997)

Elafin, an inhibitor of elastase, is a prognostic indicator in breast cancer
por: Hunt, Kelly K, et al.
Publicado: (2013)

Clinical Significance of Serum Elafin in Children with Inflammatory Bowel Disease
por: Krawiec, Paulina, et al.
Publicado: (2022)

The lysosomal protein cathepsin L is a progranulin protease
por: Lee, Chris W., et al.
Publicado: (2017)

Retrovirus Entry by Endocytosis and Cathepsin Proteases
por: Kubo, Yoshinao, et al.
Publicado: (2012)

Neurotensin-induced miR-133α expression regulates neurotensin receptor 1 recycling through its downstream target aftiphilin
por: Law, Ivy Ka Man, et al.
Publicado: (2016)

Serum Elafin as a Potential Marker of Disease Activity in Behçet's Disease
por: Kutlay, Armagan, et al.
Publicado: (2023)

Cysteine Protease Cathepsins in Atherosclerotic Cardiovascular Diseases
por: Wu, Hongxian, et al.
Publicado: (2018)

Elafin is related to immune infiltration and could predict the poor prognosis in ovarian cancer
por: Lu, Weiyu, et al.
Publicado: (2023)

Elafin and its precursor trappin‐2: What is their therapeutic potential for intestinal diseases?
por: Deraison, Céline, et al.
Publicado: (2022)

The Potential Role of the Proteases Cathepsin D and Cathepsin L in the Progression and Metastasis of Epithelial Ovarian Cancer
por: Pranjol, Md Zahidul Islam, et al.
Publicado: (2015)

The Multifaceted Role of the Lysosomal Protease Cathepsins in Kidney Disease
por: Cocchiaro, Pasquale, et al.
Publicado: (2017)

Cathepsins: Proteases that are vital for survival but can also be fatal
por: Patel, Seema, et al.
Publicado: (2018)

The Key Role of Lysosomal Protease Cathepsins in Viral Infections
por: Scarcella, Melania, et al.
Publicado: (2022)

Cathepsin S Evokes PAR(2)-Dependent Pain in Oral Squamous Cell Carcinoma Patients and Preclinical Mouse Models
por: Tu, Nguyen Huu, et al.
Publicado: (2021)

Toxoplasma Cathepsin Protease B and Aspartyl Protease 1 Are Dispensable for Endolysosomal Protein Digestion
por: McDonald, Christian, et al.
Publicado: (2020)

Human rElafin Inhibits HIV-1 Replication in Its Natural Target Cells
por: Jasinghe, Viraj J., et al.
Publicado: (2013)

Elafin is downregulated during breast and ovarian tumorigenesis but its residual expression predicts recurrence
por: Caruso, Joseph A, et al.
Publicado: (2014)

Severe Pulmonary Arterial Hypertension Is Characterized by Increased Neutrophil Elastase and Relative Elafin Deficiency
por: Sweatt, Andrew J., et al.
Publicado: (2021)

High Serum Elafin Prediction of Poor Prognosis of Locoregional Esophageal Squamous Cell Carcinoma
por: Wu, I-Chen, et al.
Publicado: (2021)

The noncanonical role of the protease cathepsin D as a cofilin phosphatase
por: Liu, Yi-Jun, et al.
Publicado: (2021)

B cell peripheral tolerance is promoted by cathepsin B protease
por: Chou, Marissa Y., et al.
Publicado: (2023)

Distinct Dibasic Cleavage Specificities of Neuropeptide-Producing Cathepsin L and Cathepsin V Cysteine Proteases Compared to PC1/3 and PC2 Serine Proteases
por: Yoon, Michael C., et al.
Publicado: (2022)

Plasma Neutrophil Elastase and Elafin Imbalance Is Associated with Acute Respiratory Distress Syndrome (ARDS) Development
por: Wang, Zhaoxi, et al.
Publicado: (2009)

Erratum to: Elafin is downregulated during breast and ovarian tumorigenesis but its residual expression predicts recurrence
por: Caruso, Joseph A, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_rrf643a6t3hheorplf5ktblrej