The HDAC inhibitor GCJ-490A suppresses c-Met expression through IKKα and overcomes gefitinib resistance in non-small cell lung cancer

OBJECTIVE: The novel compound GCJ-490A has been discovered as a pan-histone deacetylase (HDAC) inhibitor that exerts potent inhibitory activity against HDAC1, HDAC3, and HDAC6. Because of the important roles of HDACs in lung cancer development and the high distribution of GCJ-490A in lung tissue, we...

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Detalles Bibliográficos
Autores principales: He, Ting, Gao, Yinglei, Fang, Yanfen, Zhang, Yangming, Zhang, Shuwei, Nan, Fajun, Ding, Jian, Chen, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Compuscript 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9425179/
https://www.ncbi.nlm.nih.gov/pubmed/35188360
http://dx.doi.org/10.20892/j.issn.2095-3941.2021.0130

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9425179/
https://www.ncbi.nlm.nih.gov/pubmed/35188360
http://dx.doi.org/10.20892/j.issn.2095-3941.2021.0130

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