BLM helicase inhibition synergizes with PARP inhibition to improve the radiosensitivity of olaparib resistant non-small cell lung cancer cells by inhibiting homologous recombination repair

OBJECTIVE: We aimed to investigate the radiosensitizing efficacy of the poly-ADP-ribose polymerase (PARP) inhibitor, olaparib, and the Bloom syndrome protein (BLM) helicase inhibitor, ML216, in non-small cell lung cancer (NSCLC) cells. METHODS: Radiosensitization of NSCLC cells was assessed by colon...

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Detalles Bibliográficos
Autores principales: Kong, Yangyang, Xu, Chang, Sun, Xiaohui, Sun, Hao, Zhao, Xiaotong, He, Ningning, Ji, Kaihua, Wang, Qin, Du, Liqing, Wang, Jinhan, Zhang, Manman, Liu, Yang, Wang, Yan, Liu, Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Compuscript 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9425185/
https://www.ncbi.nlm.nih.gov/pubmed/34846107
http://dx.doi.org/10.20892/j.issn.2095-3941.2021.0178

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9425185/
https://www.ncbi.nlm.nih.gov/pubmed/34846107
http://dx.doi.org/10.20892/j.issn.2095-3941.2021.0178

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