The von Willebrand factor A-1 domain binding aptamer BT200 elevates plasma levels of von Willebrand factor and factor VIII: a first-in-human trial

von Willebrand factor (VWF) and factor VIII (FVIII) circulate in a noncovalent complex in blood and promote primary hemostasis and clotting, respectively. A new VWF A1-domain binding aptamer, BT200, demonstrated good subcutaneous bioavailability and a long half-life in non-human primates. This first...

Descripción completa

Detalles Bibliográficos
Autores principales: Kovacevic, Katarina D., Grafeneder, Jürgen, Schörgenhofer, Christian, Gelbenegger, Georg, Gager, Gloria, Firbas, Christa, Quehenberger, Peter, Jilma-Stohlawetz, Petra, Bileck, Andrea, Zhu, Shuhao, Gilbert, James C., Beliveau, Martin, Jilma, Bernd, Derhaschnig, Ulla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Fondazione Ferrata Storti 2021
Materias:
Article - Hemostasis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9425318/
https://www.ncbi.nlm.nih.gov/pubmed/34818873
http://dx.doi.org/10.3324/haematol.2021.279948

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9425318/
https://www.ncbi.nlm.nih.gov/pubmed/34818873
http://dx.doi.org/10.3324/haematol.2021.279948

Ejemplares similares