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The von Willebrand factor A-1 domain binding aptamer BT200 elevates plasma levels of von Willebrand factor and factor VIII: a first-in-human trial

von Willebrand factor (VWF) and factor VIII (FVIII) circulate in a noncovalent complex in blood and promote primary hemostasis and clotting, respectively. A new VWF A1-domain binding aptamer, BT200, demonstrated good subcutaneous bioavailability and a long half-life in non-human primates. This first...

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Detalles Bibliográficos
Autores principales:	Kovacevic, Katarina D., Grafeneder, Jürgen, Schörgenhofer, Christian, Gelbenegger, Georg, Gager, Gloria, Firbas, Christa, Quehenberger, Peter, Jilma-Stohlawetz, Petra, Bileck, Andrea, Zhu, Shuhao, Gilbert, James C., Beliveau, Martin, Jilma, Bernd, Derhaschnig, Ulla
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Fondazione Ferrata Storti 2021
Materias:	Article - Hemostasis
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9425318/ https://www.ncbi.nlm.nih.gov/pubmed/34818873 http://dx.doi.org/10.3324/haematol.2021.279948

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