The impact of aberrant von Willebrand factor-GPIbα interaction on megakaryopoiesis and platelets in humanized type 2B von Willebrand disease model mouse

Type 2B von Willebrand disease (VWD) is caused by gain-of-function mutations in von Willebrand factor (VWF). Increased VWF affinity for GPIbα results in loss of high molecular weight multimers and enhanced platelet clearance, both contributing to the bleeding phenotype. Severity of the symptoms vary...

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Detalles Bibliográficos
Autores principales: Kanaji, Sachiko, Morodomi, Yosuke, Weiler, Hartmut, Zarpellon, Alessandro, Montgomery, Robert R., Ruggeri, Zaverio M., Kanaji, Taisuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Fondazione Ferrata Storti 2022
Materias:
Article - Hemostasis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9425322/
https://www.ncbi.nlm.nih.gov/pubmed/35142156
http://dx.doi.org/10.3324/haematol.2021.280561

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9425322/
https://www.ncbi.nlm.nih.gov/pubmed/35142156
http://dx.doi.org/10.3324/haematol.2021.280561

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