Increased visceral fat distribution and body composition impact cytokine release syndrome onset and severity after CD19 chimeric antigen receptor T-cell therapy in advanced B-cell malignancies

Chimeric antigen receptor T-cell (CAR-T) therapy is associated with a distinct toxicity profile that includes cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS). CRS is characterized by the release of pro-inflammatory cytokines such as interleukin 6 (I...

Descripción completa

Detalles Bibliográficos
Autores principales: Cordas dos Santos, David M., Rejeski, Kai, Winkelmann, Michael, Liu, Lian, Trinkner, Paul, Günther, Sophie, Bücklein, Veit L., Blumenberg, Viktoria, Schmidt, Christian, Kunz, Wolfgang G., von Bergwelt-Baildon, Michael, Theurich, Sebastian, Subklewe, Marion
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Fondazione Ferrata Storti 2022
Materias:
Article - Cell Therapy & Immunotherapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9425325/
https://www.ncbi.nlm.nih.gov/pubmed/35172565
http://dx.doi.org/10.3324/haematol.2021.280189

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9425325/
https://www.ncbi.nlm.nih.gov/pubmed/35172565
http://dx.doi.org/10.3324/haematol.2021.280189

Ejemplares similares