A Chemical Approach to Introduce 2,6-Diaminopurine and 2-Aminoadenine Conjugates into Oligonucleotides without Need for Protecting Groups

[Image: see text] We report a simple, postsynthetic strategy for synthesis of oligonucleotides containing 2,6-diaminopurine nucleotides and 2-aminoadenine conjugates using 2-fluoro-6-amino-adenosine. The strategy allows introduction of 2,6-diaminopurine and other 2-amino group-containing ligands. Th...

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Detalles Bibliográficos
Autores principales: Madaoui, Mimouna, Datta, Dhrubajyoti, Wassarman, Kelly, Zlatev, Ivan, Egli, Martin, Ross, Bruce S., Manoharan, Muthiah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9425559/
https://www.ncbi.nlm.nih.gov/pubmed/35973215
http://dx.doi.org/10.1021/acs.orglett.2c01848

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9425559/
https://www.ncbi.nlm.nih.gov/pubmed/35973215
http://dx.doi.org/10.1021/acs.orglett.2c01848

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