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Promotion of cytoplasmic localization of oligonucleotides by connecting cross-linked duplexes
We previously reported that antisense oligonucleotides (ASOs) flanked by duplexes can suppress microRNA (miRNA) function with high efficiency for a long duration. In this study, we examined the effect of the double-stranded structure on the subcellular localization of ASOs. Double strands were cross...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society of Chemistry
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9425837/ https://www.ncbi.nlm.nih.gov/pubmed/36128385 http://dx.doi.org/10.1039/d2ra04375k |