Cargando…

Human Nasal Organoids Model SARS-CoV-2 Upper Respiratory Infection and Recapitulate the Differential Infectivity of Emerging Variants

The human upper respiratory tract, specifically the nasopharyngeal epithelium, is the entry portal and primary infection site of respiratory viruses. Productive infection of SARS-CoV-2 in the nasal epithelium constitutes the cellular basis of viral pathogenesis and transmissibility. Yet a robust and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chiu, Man Chun, Li, Cun, Liu, Xiaojuan, Song, Wenjun, Wan, Zhixin, Yu, Yifei, Huang, Jingjing, Xiao, Ding, Chu, Hin, Cai, Jian-Piao, To, Kelvin Kai-Wang, Yuen, Kwok Yung, Zhou, Jie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9426414/ https://www.ncbi.nlm.nih.gov/pubmed/35938726 http://dx.doi.org/10.1128/mbio.01944-22

Ejemplares similares

Human Intestinal Organoids Recapitulate Enteric Infections of Enterovirus and Coronavirus
por: Zhao, Xiaoyu, et al.
Publicado: (2021)

A bipotential organoid model of respiratory epithelium recapitulates high infectivity of SARS-CoV-2 Omicron variant
por: Chiu, Man Chun, et al.
Publicado: (2022)

Human airway and nasal organoids reveal escalating replicative fitness of SARS-CoV-2 emerging variants
por: Li, Cun, et al.
Publicado: (2023)

Analogous comparison unravels heightened antiviral defense and boosted viral infection upon immunosuppression in bat organoids
por: Liu, Xiaojuan, et al.
Publicado: (2022)

Establishing Bipotential Human Lung Organoid Culture System and Differentiation to Generate Mature Alveolar and Airway Organoids
por: Chiu, Man Chun, et al.
Publicado: (2023)

Differentiated human airway organoids to assess infectivity of emerging influenza virus
por: Zhou, Jie, et al.
Publicado: (2018)

Apical-Out Human Airway Organoids Modeling SARS-CoV-2 Infection
por: Chiu, Man Chun, et al.
Publicado: (2023)

An organoids biobank for recapitulating tumor heterogeneity and personalized medicine
por: Yang, Hui, et al.
Publicado: (2020)

SPINK6 inhibits human airway serine proteases and restricts influenza virus activation
por: Wang, Dong, et al.
Publicado: (2021)

Rotavirus Infection and Cytopathogenesis in Human Biliary Organoids Potentially Recapitulate Biliary Atresia Development
por: Chen, Sunrui, et al.
Publicado: (2020)

Recapitulating infection, thermal sensitivity and antiviral treatment of seasonal coronaviruses in human airway organoids
por: Li, Pengfei, et al.
Publicado: (2022)

Recapitulating influenza virus infection and facilitating antiviral and neuroprotective screening in tractable brain organoids
por: Zhang, Xiaodong, et al.
Publicado: (2022)

Benchmarking brain organoid recapitulation of fetal corticogenesis
por: Cheroni, Cristina, et al.
Publicado: (2022)

Recapitulation of SARS-CoV-2 infection and cholangiocyte damage with human liver ductal organoids
por: Zhao, Bing, et al.
Publicado: (2020)

Cellular Metabolic Heterogeneity In Vivo Is Recapitulated in Tumor Organoids()
por: Sharick, Joe T., et al.
Publicado: (2019)

Mesenchymal tumor organoid models recapitulate rhabdomyosarcoma subtypes
por: Meister, Michael T, et al.
Publicado: (2022)

An RNA-Scaffold Protein Subunit Vaccine for Nasal Immunization
por: Lam, Joy-Yan, et al.
Publicado: (2023)

SARS-CoV-2 infects human neural progenitor cells and brain organoids
por: Zhang, Bao-Zhong, et al.
Publicado: (2020)

Lizard Blastema Organoid Model Recapitulates Regenerated Tail Chondrogenesis
por: Vonk, Ariel C., et al.
Publicado: (2022)

Bioengineered Co-culture of organoids to recapitulate host-microbe interactions
por: Kim, Min Beom, et al.
Publicado: (2022)

Middle East respiratory syndrome coronavirus infection: virus-host cell interactions and implications on pathogenesis
por: Zhou, Jie, et al.
Publicado: (2015)

In memory of Patrick Manson, founding father of tropical medicine and the discovery of vector-borne infections
por: To, Kelvin KW, et al.
Publicado: (2012)

A broad-spectrum virus- and host-targeting peptide against respiratory viruses including influenza virus and SARS-CoV-2
por: Zhao, Hanjun, et al.
Publicado: (2020)

Retinal Organoids from Pluripotent Stem Cells Efficiently Recapitulate Retinogenesis
por: Völkner, Manuela, et al.
Publicado: (2016)

Human heart-forming organoids recapitulate early heart and foregut development
por: Drakhlis, Lika, et al.
Publicado: (2021)

Kidney organoids recapitulate human basement membrane assembly in health and disease
por: Morais, Mychel RPT, et al.
Publicado: (2022)

Generation of innervated cochlear organoid recapitulates early development of auditory unit
por: Xia, Mingyu, et al.
Publicado: (2022)

Identification and characterization of GLDC as host susceptibility gene to severe influenza
por: Zhou, Jie, et al.
Publicado: (2018)

Pathogenicity of SARS‐CoV‐2 Omicron
por: Chu, Hin, et al.
Publicado: (2022)

Human coronavirus dependency on host heat shock protein 90 reveals an antiviral target
por: Li, Cun, et al.
Publicado: (2020)

SARS-CoV-2 infection induces inflammatory bone loss in golden Syrian hamsters
por: Qiao, Wei, et al.
Publicado: (2022)

Author Correction: SARS-CoV-2 infection induces inflammatory bone loss in golden Syrian hamsters
por: Qiao, Wei, et al.
Publicado: (2022)

Self-Renewing Trophoblast Organoids Recapitulate the Developmental Program of the Early Human Placenta
por: Haider, Sandra, et al.
Publicado: (2018)

Induced organoids derived from patients with ulcerative colitis recapitulate colitic reactivity
por: Sarvestani, Samaneh K., et al.
Publicado: (2021)

In Vitro Recapitulation of Neuropsychiatric Disorders with Pluripotent Stem Cells-Derived Brain Organoids
por: Gulimiheranmu, Maisumu, et al.
Publicado: (2021)

Organoids in recapitulating tumorigenesis driven by risk factors: Current trends and future perspectives
por: Zhang, Jie, et al.
Publicado: (2022)

Intranasal Boosting with Spike Fc-RBD of Wild-Type SARS-CoV-2 Induces Neutralizing Antibodies against Omicron Subvariants and Reduces Viral Load in the Nasal Turbinate of Mice
por: Cai, Jian-Piao, et al.
Publicado: (2023)

SARS-CoV-2 hijacks neutralizing dimeric IgA for nasal infection and injury in Syrian hamsters(1)
por: Zhou, Biao, et al.
Publicado: (2023)

Cerebral organoids exhibit mature neurons and astrocytes and recapitulate electrophysiological activity of the human brain
por: Yakoub, Abraam M.
Publicado: (2019)

Outgrowth of erlotinib-resistant subpopulations recapitulated in patient-derived lung tumor spheroids and organoids
por: Banda, Malathi, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_veir8ppfcqa9ksb5hcj040oglr