MX2 Viral Substrate Breadth and Inhibitory Activity Are Regulated by Protein Phosphorylation

Human immunodeficiency virus type-1 (HIV-1) infection is potently inhibited by human myxovirus resistance 2 (MX2/MxB), which binds to the viral capsid and blocks the nuclear import of viral DNA. We have recently shown that phosphorylation is a key regulator of MX2 antiviral activity, with phosphoryl...

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Detalles Bibliográficos
Autores principales: Betancor, Gilberto, Bangham, Madeleine, Jeon, Jun Ki, Shah, Kanisha, Lynham, Steven, Jimenez-Guardeño, Jose M., Malim, Michael H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9426416/
https://www.ncbi.nlm.nih.gov/pubmed/35880880
http://dx.doi.org/10.1128/mbio.01714-22

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9426416/
https://www.ncbi.nlm.nih.gov/pubmed/35880880
http://dx.doi.org/10.1128/mbio.01714-22

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