Impact of SARS-CoV-2 Spike Mutations on Its Activation by TMPRSS2 and the Alternative TMPRSS13 Protease

The continuous emergence of new variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) urges better understanding of the functional motifs in the spike (S) protein and their tolerance to mutations. Here, we focused on the S2′ motif, which, during virus entry, requires cleavage by a...

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Detalles Bibliográficos
Autores principales: Stevaert, Annelies, Van Berwaer, Ria, Mestdagh, Cato, Vandeput, Julie, Vanstreels, Els, Raeymaekers, Valerie, Laporte, Manon, Naesens, Lieve
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Observation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9426466/
https://www.ncbi.nlm.nih.gov/pubmed/35913162
http://dx.doi.org/10.1128/mbio.01376-22

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9426466/
https://www.ncbi.nlm.nih.gov/pubmed/35913162
http://dx.doi.org/10.1128/mbio.01376-22

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