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The Akt Forkhead Box O Transcription Factor Axis Regulates Human Cytomegalovirus Replication

The protein kinase Akt broadly impacts many cellular processes, including mRNA translation, metabolism, apoptosis, and stress responses. Inhibition of phosphatidylinositol 3-kinase (PI3K), a lipid kinase pivotal to Akt activation, triggers various herpesviruses to reactivate from latency. Hence, dec...

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Detalles Bibliográficos
Autores principales: Zhang, Hongbo, Domma, Anthony J., Goodrum, Felicia D., Moorman, Nathaniel J., Kamil, Jeremy P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9426471/
https://www.ncbi.nlm.nih.gov/pubmed/35946797
http://dx.doi.org/10.1128/mbio.01042-22