Blockade of the Adenylate Cyclase Toxin Synergizes with Opsonizing Antibodies to Protect Mice against Bordetella pertussis

Bordetella produces an array of virulence factors, including the adenylate cyclase toxin (ACT), which is essential, immunogenic in humans, and highly conserved. Despite mediating immune-evasive functions as a leukotoxin, ACT’s potential role as a protective antigen is unclear. To better understand t...

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Detalles Bibliográficos
Autores principales: DiVenere, Andrea M., Amengor, Dzifa, Silva, Rui P., Goldsmith, Jory A., McLellan, Jason S., Maynard, Jennifer A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9426472/
https://www.ncbi.nlm.nih.gov/pubmed/35920558
http://dx.doi.org/10.1128/mbio.01527-22

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9426472/
https://www.ncbi.nlm.nih.gov/pubmed/35920558
http://dx.doi.org/10.1128/mbio.01527-22

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