A Variant Allele in Varicella-Zoster Virus Glycoprotein B Selected during Production of the Varicella Vaccine Contributes to Its Attenuation

Attenuation of the live varicella Oka vaccine (vOka) has been attributed to mutations in the genome acquired during cell culture passage of pOka (parent strain); however, the precise mechanisms of attenuation remain unknown. Comparative sequence analyses of several vaccine batches showed that over 1...

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Detalles Bibliográficos
Autores principales: Sadaoka, Tomohiko, Depledge, Daniel P., Rajbhandari, Labchan, Breuer, Judith, Venkatesan, Arun, Cohen, Jeffrey I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9426484/
https://www.ncbi.nlm.nih.gov/pubmed/35916400
http://dx.doi.org/10.1128/mbio.01864-22

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9426484/
https://www.ncbi.nlm.nih.gov/pubmed/35916400
http://dx.doi.org/10.1128/mbio.01864-22

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