Effect of Baloxavir and Oseltamivir in Combination on Infection with Influenza Viruses with PA/I38T or PA/E23K Substitutions in the Ferret Model

Amino acid substitutions I38T and E23K in the influenza polymerase acidic (PA) protein lead to reduced susceptibility to the influenza antiviral drug baloxavir. The in vivo effectiveness of baloxavir and oseltamivir for treatment of these viruses is currently unknown. Using patient-derived influenza...

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Detalles Bibliográficos
Autores principales: Koszalka, Paulina, George, Ankita, Dhanasekaran, Vijaykrishna, Hurt, Aeron C., Subbarao, Kanta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9426601/
https://www.ncbi.nlm.nih.gov/pubmed/35938724
http://dx.doi.org/10.1128/mbio.01056-22

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9426601/
https://www.ncbi.nlm.nih.gov/pubmed/35938724
http://dx.doi.org/10.1128/mbio.01056-22

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