Blocking T‐cell egress with FTY720 extends DNA vaccine expression but reduces immunogenicity

Optimal immunogenicity from nucleic acid vaccines requires a balance of antigen expression that effectively engages the host immune system without generating a cellular response that rapidly destroys cells producing the antigen and thereby limiting vaccine antigen expression. We investigated the rol...

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Detalles Bibliográficos
Autores principales: Mann, Jamie F. S., McKay, Paul F., Klein, Katja, Pankrac, Joshua, Tregoning, John S., Shattock, Robin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9426614/
https://www.ncbi.nlm.nih.gov/pubmed/34775601
http://dx.doi.org/10.1111/imm.13429

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9426614/
https://www.ncbi.nlm.nih.gov/pubmed/34775601
http://dx.doi.org/10.1111/imm.13429

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