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Blocking T‐cell egress with FTY720 extends DNA vaccine expression but reduces immunogenicity
Optimal immunogenicity from nucleic acid vaccines requires a balance of antigen expression that effectively engages the host immune system without generating a cellular response that rapidly destroys cells producing the antigen and thereby limiting vaccine antigen expression. We investigated the rol...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9426614/ https://www.ncbi.nlm.nih.gov/pubmed/34775601 http://dx.doi.org/10.1111/imm.13429 |