Itaconate and fumarate derivatives inhibit priming and activation of the canonical NLRP3 inflammasome in macrophages

The NLRP3 inflammasome is a multiprotein complex that regulates caspase‐1 activation and subsequent interleukin (IL)‐1β and IL‐18 release from innate immune cells in response to infection or injury. Derivatives of the metabolites itaconate and fumarate, dimethyl itaconate (DMI), 4‐octyl itaconate (4...

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Detalles Bibliográficos
Autores principales: Hoyle, Christopher, Green, Jack P., Allan, Stuart M., Brough, David, Lemarchand, Eloise
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9426622/
https://www.ncbi.nlm.nih.gov/pubmed/35137954
http://dx.doi.org/10.1111/imm.13454

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9426622/
https://www.ncbi.nlm.nih.gov/pubmed/35137954
http://dx.doi.org/10.1111/imm.13454

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