Stress hormone signalling inhibits Th1 polarization in a CD4 T‐cell‐intrinsic manner via mTORC1 and the circadian gene PER1

Stress hormones are believed to skew the CD4 T‐cell differentiation towards a Th2 response via a T‐cell‐extrinsic mechanism. Using isolated primary human naïve and memory CD4 T cells, here we show that both adrenergic‐ and glucocorticoid‐mediated stress signalling pathways play a CD4 naïve T‐cell‐in...

Descripción completa

Detalles Bibliográficos
Autores principales: Capelle, Christophe M., Chen, Anna, Zeng, Ni, Baron, Alexandre, Grzyb, Kamil, Arns, Thais, Skupin, Alexander, Ollert, Markus, Hefeng, Feng Q.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9426625/
https://www.ncbi.nlm.nih.gov/pubmed/35143696
http://dx.doi.org/10.1111/imm.13448

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9426625/
https://www.ncbi.nlm.nih.gov/pubmed/35143696
http://dx.doi.org/10.1111/imm.13448

Ejemplares similares