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Stress hormone signalling inhibits Th1 polarization in a CD4 T‐cell‐intrinsic manner via mTORC1 and the circadian gene PER1
Stress hormones are believed to skew the CD4 T‐cell differentiation towards a Th2 response via a T‐cell‐extrinsic mechanism. Using isolated primary human naïve and memory CD4 T cells, here we show that both adrenergic‐ and glucocorticoid‐mediated stress signalling pathways play a CD4 naïve T‐cell‐in...
Autores principales: | Capelle, Christophe M., Chen, Anna, Zeng, Ni, Baron, Alexandre, Grzyb, Kamil, Arns, Thais, Skupin, Alexander, Ollert, Markus, Hefeng, Feng Q. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9426625/ https://www.ncbi.nlm.nih.gov/pubmed/35143696 http://dx.doi.org/10.1111/imm.13448 |
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