CDK4: a master regulator of the cell cycle and its role in cancer

The cell cycle is regulated in part by cyclins and their associated serine/threonine cyclin-dependent kinases, or CDKs. CDK4, in conjunction with the D-type cyclins, mediates progression through the G(1) phase when the cell prepares to initiate DNA synthesis. Although Cdk4-null mutant mice are viabl...

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Autores principales: Baker, Stacey J., Poulikakos, Poulikos I., Irie, Hanna Y., Parekh, Samir, Reddy, E. Premkumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9426627/
https://www.ncbi.nlm.nih.gov/pubmed/36051751
http://dx.doi.org/10.18632/genesandcancer.221
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author Baker, Stacey J.
Poulikakos, Poulikos I.
Irie, Hanna Y.
Parekh, Samir
Reddy, E. Premkumar
author_facet Baker, Stacey J.
Poulikakos, Poulikos I.
Irie, Hanna Y.
Parekh, Samir
Reddy, E. Premkumar
author_sort Baker, Stacey J.
collection PubMed
description The cell cycle is regulated in part by cyclins and their associated serine/threonine cyclin-dependent kinases, or CDKs. CDK4, in conjunction with the D-type cyclins, mediates progression through the G(1) phase when the cell prepares to initiate DNA synthesis. Although Cdk4-null mutant mice are viable and cell proliferation is not significantly affected in vitro due to compensatory roles played by other CDKs, this gene plays a key role in mammalian development and cancer. This review discusses the role that CDK4 plays in cell cycle control, normal development and tumorigenesis as well as the current status and utility of approved small molecule CDK4/6 inhibitors that are currently being used as cancer therapeutics.
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spelling pubmed-94266272022-08-31 CDK4: a master regulator of the cell cycle and its role in cancer Baker, Stacey J. Poulikakos, Poulikos I. Irie, Hanna Y. Parekh, Samir Reddy, E. Premkumar Genes Cancer Review The cell cycle is regulated in part by cyclins and their associated serine/threonine cyclin-dependent kinases, or CDKs. CDK4, in conjunction with the D-type cyclins, mediates progression through the G(1) phase when the cell prepares to initiate DNA synthesis. Although Cdk4-null mutant mice are viable and cell proliferation is not significantly affected in vitro due to compensatory roles played by other CDKs, this gene plays a key role in mammalian development and cancer. This review discusses the role that CDK4 plays in cell cycle control, normal development and tumorigenesis as well as the current status and utility of approved small molecule CDK4/6 inhibitors that are currently being used as cancer therapeutics. Impact Journals LLC 2022-08-25 /pmc/articles/PMC9426627/ /pubmed/36051751 http://dx.doi.org/10.18632/genesandcancer.221 Text en https://creativecommons.org/licenses/by/3.0/Copyright: © 2022 Baker et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Review
Baker, Stacey J.
Poulikakos, Poulikos I.
Irie, Hanna Y.
Parekh, Samir
Reddy, E. Premkumar
CDK4: a master regulator of the cell cycle and its role in cancer
title CDK4: a master regulator of the cell cycle and its role in cancer
title_full CDK4: a master regulator of the cell cycle and its role in cancer
title_fullStr CDK4: a master regulator of the cell cycle and its role in cancer
title_full_unstemmed CDK4: a master regulator of the cell cycle and its role in cancer
title_short CDK4: a master regulator of the cell cycle and its role in cancer
title_sort cdk4: a master regulator of the cell cycle and its role in cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9426627/
https://www.ncbi.nlm.nih.gov/pubmed/36051751
http://dx.doi.org/10.18632/genesandcancer.221
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