Ischemia-Selective Cardioprotection by Malonate for Ischemia/Reperfusion Injury
Inhibiting SDH (succinate dehydrogenase), with the competitive inhibitor malonate, has shown promise in ameliorating ischemia/reperfusion injury. However, key for translation to the clinic is understanding the mechanism of malonate entry into cells to enable inhibition of SDH, its mitochondrial targ...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9426742/ https://www.ncbi.nlm.nih.gov/pubmed/35959683 http://dx.doi.org/10.1161/CIRCRESAHA.121.320717 |