Ischemia-Selective Cardioprotection by Malonate for Ischemia/Reperfusion Injury

Inhibiting SDH (succinate dehydrogenase), with the competitive inhibitor malonate, has shown promise in ameliorating ischemia/reperfusion injury. However, key for translation to the clinic is understanding the mechanism of malonate entry into cells to enable inhibition of SDH, its mitochondrial targ...

Descripción completa

Detalles Bibliográficos
Autores principales: Prag, Hiran A., Aksentijevic, Dunja, Dannhorn, Andreas, Giles, Abigail V., Mulvey, John F., Sauchanka, Olga, Du, Luping, Bates, Georgina, Reinhold, Johannes, Kula-Alwar, Duvaraka, Xu, Zhelong, Pellerin, Luc, Goodwin, Richard J. A., Murphy, Michael P., Krieg, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9426742/
https://www.ncbi.nlm.nih.gov/pubmed/35959683
http://dx.doi.org/10.1161/CIRCRESAHA.121.320717