Ischemia-Selective Cardioprotection by Malonate for Ischemia/Reperfusion Injury

Inhibiting SDH (succinate dehydrogenase), with the competitive inhibitor malonate, has shown promise in ameliorating ischemia/reperfusion injury. However, key for translation to the clinic is understanding the mechanism of malonate entry into cells to enable inhibition of SDH, its mitochondrial targ...

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Detalles Bibliográficos
Autores principales: Prag, Hiran A., Aksentijevic, Dunja, Dannhorn, Andreas, Giles, Abigail V., Mulvey, John F., Sauchanka, Olga, Du, Luping, Bates, Georgina, Reinhold, Johannes, Kula-Alwar, Duvaraka, Xu, Zhelong, Pellerin, Luc, Goodwin, Richard J. A., Murphy, Michael P., Krieg, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9426742/
https://www.ncbi.nlm.nih.gov/pubmed/35959683
http://dx.doi.org/10.1161/CIRCRESAHA.121.320717

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