Targeting SIRT1 Rescues Age- and Obesity-Induced Microvascular Dysfunction in Ex Vivo Human Vessels

Experimental evidence suggests a key role of SIRT1 (silent information regulator 1) in age- and metabolic-related vascular dysfunction. Whether these effects hold true in the human microvasculature is unknown. We aimed to investigate the SIRT1 role in very early stages of age- and obesity-related mi...

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Detalles Bibliográficos
Autores principales: Mengozzi, Alessandro, Costantino, Sarah, Paneni, Francesco, Duranti, Emiliano, Nannipieri, Monica, Mancini, Rudj, Lai, Michele, La Rocca, Veronica, Puxeddu, Ilaria, Antonioli, Luca, Fornai, Matteo, Ghionzoli, Marco, Georgiopoulos, Georgios, Ippolito, Chiara, Bernardini, Nunzia, Ruschitzka, Frank, Pugliese, Nicola Riccardo, Taddei, Stefano, Virdis*, Agostino, Masi, Stefano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9426744/
https://www.ncbi.nlm.nih.gov/pubmed/35968712
http://dx.doi.org/10.1161/CIRCRESAHA.122.320888

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9426744/
https://www.ncbi.nlm.nih.gov/pubmed/35968712
http://dx.doi.org/10.1161/CIRCRESAHA.122.320888

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