Cargando…
Targeting SIRT1 Rescues Age- and Obesity-Induced Microvascular Dysfunction in Ex Vivo Human Vessels
Experimental evidence suggests a key role of SIRT1 (silent information regulator 1) in age- and metabolic-related vascular dysfunction. Whether these effects hold true in the human microvasculature is unknown. We aimed to investigate the SIRT1 role in very early stages of age- and obesity-related mi...
Autores principales: | Mengozzi, Alessandro, Costantino, Sarah, Paneni, Francesco, Duranti, Emiliano, Nannipieri, Monica, Mancini, Rudj, Lai, Michele, La Rocca, Veronica, Puxeddu, Ilaria, Antonioli, Luca, Fornai, Matteo, Ghionzoli, Marco, Georgiopoulos, Georgios, Ippolito, Chiara, Bernardini, Nunzia, Ruschitzka, Frank, Pugliese, Nicola Riccardo, Taddei, Stefano, Virdis*, Agostino, Masi, Stefano |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9426744/ https://www.ncbi.nlm.nih.gov/pubmed/35968712 http://dx.doi.org/10.1161/CIRCRESAHA.122.320888 |
Ejemplares similares
-
Donepezil improves vascular function in a mouse model of Alzheimer’s disease
por: Pellegrini, Carolina, et al.
Publicado: (2021) -
The renal resistive index is associated with microvascular remodeling in patients with severe obesity
por: Moriconi, Diego, et al.
Publicado: (2023) -
Epigenetic Signatures in Arterial Hypertension: Focus on the Microvasculature
por: Mengozzi, Alessandro, et al.
Publicado: (2023) -
Treatment with recombinant Sirt1 rewires the cardiac lipidome and rescues diabetes-related metabolic cardiomyopathy
por: Costantino, Sarah, et al.
Publicado: (2023) -
Oxidative Stress and Vascular Damage in Hypertension: Role of Angiotensin II
por: Virdis, Agostino, et al.
Publicado: (2011)