PI3K signaling specifies proximal-distal fate by driving a developmental gene regulatory network in SOX9+ mouse lung progenitors

The tips of the developing respiratory buds are home to important progenitor cells marked by the expression of SOX9 and ID2. Early in embryonic development (prior to E13.5), SOX9+progenitors are multipotent, generating both airway and alveolar epithelium, but are selective progenitors of alveolar ep...

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Detalles Bibliográficos
Autores principales: Khattar, Divya, Fernandes, Sharlene, Snowball, John, Guo, Minzhe, Gillen, Matthew C, Jain, Suchi Singh, Sinner, Debora, Zacharias, William, Swarr, Daniel T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9427112/
https://www.ncbi.nlm.nih.gov/pubmed/35976093
http://dx.doi.org/10.7554/eLife.67954

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9427112/
https://www.ncbi.nlm.nih.gov/pubmed/35976093
http://dx.doi.org/10.7554/eLife.67954

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