NMR analysis suggests the terminal domains of Robo1 remain extended but are rigidified in the presence of heparan sulfate

Human roundabout 1 (hRobo1) is an extracellular receptor glycoprotein that plays important roles in angiogenesis, organ development, and tumor progression. Interaction between hRobo1 and heparan sulfate (HS) has been shown to be essential for its biological activity. To better understand the effect...

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Detalles Bibliográficos
Autores principales: Williams, Robert V., Huang, Chin, Moremen, Kelley W., Amster, I. Jonathan, Prestegard, James H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9427851/
https://www.ncbi.nlm.nih.gov/pubmed/36042257
http://dx.doi.org/10.1038/s41598-022-18769-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9427851/
https://www.ncbi.nlm.nih.gov/pubmed/36042257
http://dx.doi.org/10.1038/s41598-022-18769-6

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