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NMR analysis suggests the terminal domains of Robo1 remain extended but are rigidified in the presence of heparan sulfate
Human roundabout 1 (hRobo1) is an extracellular receptor glycoprotein that plays important roles in angiogenesis, organ development, and tumor progression. Interaction between hRobo1 and heparan sulfate (HS) has been shown to be essential for its biological activity. To better understand the effect...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9427851/ https://www.ncbi.nlm.nih.gov/pubmed/36042257 http://dx.doi.org/10.1038/s41598-022-18769-6 |