A multi-functional role for the MCM8/9 helicase complex in maintaining fork integrity during replication stress

The minichromosome maintenance (MCM) 8/9 helicase is a AAA(+) complex involved in DNA replication-associated repair. Despite high sequence homology to the MCM2-7 helicase, a precise cellular role for MCM8/9 has remained elusive. We have interrogated the DNA synthesis ability and replication fork sta...

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Detalles Bibliográficos
Autores principales: Griffin, Wezley C., McKinzey, David R., Klinzing, Kathleen N., Baratam, Rithvik, Eliyapura, Achini, Trakselis, Michael A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9427862/
https://www.ncbi.nlm.nih.gov/pubmed/36042199
http://dx.doi.org/10.1038/s41467-022-32583-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9427862/
https://www.ncbi.nlm.nih.gov/pubmed/36042199
http://dx.doi.org/10.1038/s41467-022-32583-8

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