Simultaneous targeting of glycolysis and oxidative phosphorylation as a therapeutic strategy to treat diffuse large B-cell lymphoma

BACKGROUND: We evaluated the therapeutic potential of combining the monocarboxylate transporter 1 (MCT1) inhibitor AZD3965 with the mitochondrial respiratory Complex I inhibitor IACS-010759, for the treatment of diffuse large B-cell lymphoma (DLBCL), a potential clinically actionable strategy to tar...

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Detalles Bibliográficos
Autores principales: Noble, Richard A., Thomas, Huw, Zhao, Yan, Herendi, Lili, Howarth, Rachel, Dragoni, Ilaria, Keun, Hector C., Vellano, Christopher P., Marszalek, Joseph R., Wedge, Stephen R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9428179/
https://www.ncbi.nlm.nih.gov/pubmed/35618788
http://dx.doi.org/10.1038/s41416-022-01848-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9428179/
https://www.ncbi.nlm.nih.gov/pubmed/35618788
http://dx.doi.org/10.1038/s41416-022-01848-w

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