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Simultaneous targeting of glycolysis and oxidative phosphorylation as a therapeutic strategy to treat diffuse large B-cell lymphoma

BACKGROUND: We evaluated the therapeutic potential of combining the monocarboxylate transporter 1 (MCT1) inhibitor AZD3965 with the mitochondrial respiratory Complex I inhibitor IACS-010759, for the treatment of diffuse large B-cell lymphoma (DLBCL), a potential clinically actionable strategy to tar...

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Detalles Bibliográficos
Autores principales:	Noble, Richard A., Thomas, Huw, Zhao, Yan, Herendi, Lili, Howarth, Rachel, Dragoni, Ilaria, Keun, Hector C., Vellano, Christopher P., Marszalek, Joseph R., Wedge, Stephen R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9428179/ https://www.ncbi.nlm.nih.gov/pubmed/35618788 http://dx.doi.org/10.1038/s41416-022-01848-w

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