Simultaneous absolute protein quantification of seven cytochrome P450 isoforms in rat liver microsomes by LC-MS/MS-based isotope internal standard method

The cytochrome P450 (CYP) enzymes play a pivotal role in drug metabolism. LC-MS/MS-based targeting technology has been applied to the analysis of CYP enzymes, promoting drug development and drug-drug interaction studies. Rat is one of the most commonly used models for drug metabolism assessment, but...

Descripción completa

Detalles Bibliográficos
Autores principales: Jiang, Fulin, Zhang, Chang, Lu, Zihan, Liu, Jingyu, Liu, Peiqing, Huang, Min, Zhong, Guoping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9428253/
https://www.ncbi.nlm.nih.gov/pubmed/36059965
http://dx.doi.org/10.3389/fphar.2022.906027

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9428253/
https://www.ncbi.nlm.nih.gov/pubmed/36059965
http://dx.doi.org/10.3389/fphar.2022.906027

Ejemplares similares