Cargando…

Simultaneous absolute protein quantification of seven cytochrome P450 isoforms in rat liver microsomes by LC-MS/MS-based isotope internal standard method

The cytochrome P450 (CYP) enzymes play a pivotal role in drug metabolism. LC-MS/MS-based targeting technology has been applied to the analysis of CYP enzymes, promoting drug development and drug-drug interaction studies. Rat is one of the most commonly used models for drug metabolism assessment, but...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jiang, Fulin, Zhang, Chang, Lu, Zihan, Liu, Jingyu, Liu, Peiqing, Huang, Min, Zhong, Guoping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9428253/ https://www.ncbi.nlm.nih.gov/pubmed/36059965 http://dx.doi.org/10.3389/fphar.2022.906027

Ejemplares similares

Signal Suppression in LC-ESI-MS/MS from Concomitant Medications and Its Impact on Quantitative Studies: An Example Using Metformin and Glyburide
por: Liu, Jingyu, et al.
Publicado: (2023)

Evaluation of the inhibition potential of plumbagin against cytochrome P450 using LC-MS/MS and cocktail approach
por: Chen, Ang, et al.
Publicado: (2016)

Human Cytochrome P450 Enzyme Modulation by Gymnema sylvestre: A Predictive Safety Evaluation by LC-MS/MS
por: Rammohan, Bera, et al.
Publicado: (2016)

Quantification of cGMP in human plasma by isotope dilution LC-MS/MS
por: Martens-Lobenhoffer, Jens, et al.
Publicado: (2009)

A validated LC-MS/MS analytical method for the quantification of pemigatinib: metabolic stability evaluation in human liver microsomes
por: Attwa, Mohamed W., et al.
Publicado: (2022)

Development of an LC-MS/MS Method for Quantification of Sapitinib in Human Liver Microsomes: In Silico and In Vitro Metabolic Stability Evaluation
por: Attwa, Mohamed W., et al.
Publicado: (2023)

Absolute quantification of endogenous angiotensin II levels in human plasma using ESI-LC-MS/MS
por: Schulz, Anna, et al.
Publicado: (2014)

LC–MS/MS Estimation of Rociletinib Levels in Human Liver Microsomes: Application to Metabolic Stability Estimation
por: Attwa, Mohamed W, et al.
Publicado: (2021)

Identification of In Vitro Metabolites of Amoxicillin in Human Liver Microsomes by LC–ESI/MS
por: Szultka, Malgorzata, et al.
Publicado: (2014)

Monitoring diacylglycerols in biofluids by non-isotopically paired charge derivatization combined with LC-MS/MS
por: Liu, Yang-Dan, et al.
Publicado: (2022)

Inhibition of Cytochrome P450 by Propolis in Human Liver Microsomes
por: Ryu, Chang Seon, et al.
Publicado: (2016)

LC–MS-based absolute metabolite quantification: application to metabolic flux measurement in trypanosomes
por: Kim, Dong-Hyun, et al.
Publicado: (2015)

An isotope dilution LC–MS/MS-based candidate reference method for the quantification of androstenedione in human serum and plasma
por: Gradl, Katrin, et al.
Publicado: (2020)

Isotopic labeling-assisted metabolomics using LC–MS
por: Bueschl, C., et al.
Publicado: (2012)

Quantitative LC-MS/MS analysis of seven ginsenosides and three aconitum alkaloids in Shen-Fu decoction
por: Guo, Na, et al.
Publicado: (2013)

MRCQuant- an accurate LC-MS relative isotopic quantification algorithm on TOF instruments
por: Haskins, William E, et al.
Publicado: (2011)

LC-MS/MS Estimation of the Anti-Cancer Agent Tandutinib Levels in Human Liver Microsomes: Metabolic Stability Evaluation Assay
por: Attwa, Mohamed W, et al.
Publicado: (2020)

Metabolite Identification of a Novel Anti-Leishmanial Agent OJT007 in Rat Liver Microsomes Using LC-MS/MS
por: Rincon Nigro, Maria Eugenia, et al.
Publicado: (2022)

Assessment of In Silico and In Vitro Selpercatinib Metabolic Stability in Human Liver Microsomes Using a Validated LC-MS/MS Method
por: Attwa, Mohamed W., et al.
Publicado: (2023)

Inhibition of cytochrome P450 enzymes by thymoquinone in human liver microsomes
por: Albassam, Ahmed A., et al.
Publicado: (2018)

Analysis of Methionine Oxidation in Myosin Isoforms in Porcine Skeletal Muscle by LC-MS/MS Analysis
por: Jeong, Jin-Yeon, et al.
Publicado: (2016)

UPLC/MS MS data of testosterone metabolites in human and zebrafish liver microsomes and whole zebrafish larval microsomes
por: Saad, Moayad, et al.
Publicado: (2017)

Stoichiometric Quantification of Akt Phosphorylation Using LC-MS/MS
por: Atrih, Abdelmadjid, et al.
Publicado: (2009)

The potential for isotope dilution-LC-MS/MS to improve laboratory measurement of C-peptide: Reasons and critical determinants
por: Deng, Yuhang, et al.
Publicado: (2021)

Selective quantification of the 22-kDa isoform of human growth hormone 1 in serum and plasma by immunocapture and LC–MS/MS
por: Sleumer, Bas, et al.
Publicado: (2022)

Peak Pair Pruner: a post-processing software to MS-DIAL for peak pair validation and ratio quantification of isotopic labeling LC-MS(/MS) data
por: Smith, Ryan A, et al.
Publicado: (2023)

Absolute quantification of DcR3 and GDF15 from human serum by LC-ESI MS
por: Lancrajan, Ioana, et al.
Publicado: (2015)

Characterization of Stable and Reactive Metabolites of the Anticancer Drug, Ensartinib, in Human Liver Microsomes Using LC-MS/MS: An in silico and Practical Bioactivation Approach
por: Abdelhameed, Ali S, et al.
Publicado: (2020)

Development and Validation of a Rapid LC-MS/MS Method for Quantifying Alvocidib: In Silico and In Vitro Metabolic Stability Estimation in Human Liver Microsomes
por: Attwa, Mohamed W., et al.
Publicado: (2023)

Evaluation of the effects of four types of tea on the activity of cytochrome P450 enzymes with a probe cocktail and HPLC-MS/MS
por: Wang, Xueyan, et al.
Publicado: (2022)

LC, MS(n) and LC–MS/MS studies for the characterization of degradation products of amlodipine
por: Tiwari, Ravi N., et al.
Publicado: (2015)

Liver microsomal lipid enhances the activity and redox coupling of colocalized cytochrome P450 reductase‐cytochrome P450 3A4 in nanodiscs
por: Liu, Kang‐Cheng, et al.
Publicado: (2017)

Absolute bioavailability, dose proportionality, and tissue distribution of rotundic acid in rats based on validated LC-QqQ-MS/MS method
por: Shang, Haihua, et al.
Publicado: (2022)

Isobaric 4-Plex Tagging for Absolute Quantitation of Biological Acids in Diabetic Urine Using Capillary LC–MS/MS
por: Armbruster, Michael R., et al.
Publicado: (2022)

Largazole Pharmacokinetics in Rats by LC-MS/MS
por: Yu, Mingming, et al.
Publicado: (2014)

Pipelines and Systems for Threshold-Avoiding Quantification of LC–MS/MS Data
por: Sánchez Brotons, Alejandro, et al.
Publicado: (2021)

Estimation of measurement uncertainty for the quantification of protein by ID-LC–MS/MS
por: Beasley-Green, Ashley, et al.
Publicado: (2023)

Application of large volume injection for sensitive LC-MS/MS analysis of seven artificial sweeteners in surface waters
por: Henschel, Jonas, et al.
Publicado: (2020)

Peptide Biomarkers Discovery for Seven Species of Deer Antler Using LC-MS/MS and Label-Free Approach
por: Xue, Fei, et al.
Publicado: (2022)

Effects of Eleutheroside B and Eleutheroside E on activity of cytochrome P450 in rat liver microsomes
por: Guo, Sixun, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_qpnla3lbchmtgmg6267f8q7e4p