Structural guidelines for stabilization of α-helical coiled coils via PEG stapling

Macrocyclization or stapling is one of the most well-known and generally applicable strategies for enhancing peptide/protein conformational stability and target binding affinity. However, there are limited structure- or sequence-based guidelines for the incorporation of optimal interhelical staples...

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Detalles Bibliográficos
Autores principales: Xiao, Qiang, Jones, Zachary B., Hatfield, Samantha C., Ashton, Dallin S., Dalley, Nicholas A., Dyer, Cody D., Evangelista, Judah L., Price, Joshua L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9428657/
https://www.ncbi.nlm.nih.gov/pubmed/36128502
http://dx.doi.org/10.1039/d1cb00237f

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9428657/
https://www.ncbi.nlm.nih.gov/pubmed/36128502
http://dx.doi.org/10.1039/d1cb00237f

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