Cereblon covalent modulation through structure-based design of histidine targeting chemical probes

Electrophilic biocompatible warheads, particularly cysteine-reactive acrylamides, have enabled the development of covalent inhibitor drugs and chemical biology probes, but cysteine is rarely present in protein binding sites. Therefore, expansion of the list of targetable amino acid residues is requi...

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Detalles Bibliográficos
Autores principales: Cruite, Justin T., Dann, Geoffrey P., Che, Jianwei, Donovan, Katherine A., Ferrao, Silas, Ficarro, Scott B., Fischer, Eric S., Gray, Nathanael S., Huerta, Fidel, Kong, Nikki R., Liu, Hu, Marto, Jarrod A., Metivier, Rebecca J., Nowak, Radosław P., Zerfas, Breanna L., Jones, Lyn H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9428674/
https://www.ncbi.nlm.nih.gov/pubmed/36128501
http://dx.doi.org/10.1039/d2cb00078d

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9428674/
https://www.ncbi.nlm.nih.gov/pubmed/36128501
http://dx.doi.org/10.1039/d2cb00078d

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